BAIT

HECW2

NEDL2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
UPS Project
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

TOMM34

HTOM34P, TOM34, URCC3
translocase of outer mitochondrial membrane 34
GO Process (1)
GO Function (1)
GO Component (6)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

HECT Type Ubiquitin Ligase NEDL2 is Degraded by APC/C-Cdh1 and its Tight Regulation Maintains the Metaphase to Anaphase Transition.

Lu L, Hu S, Wei R, Qiu X, Lu K, Fu Y, Li H, Xing G, Li D, Peng R, He F, Zhang L

NEDD4-like ubiquitin ligase 2 (NEDL2) is a HECT type ubiquitin ligase. NEDL2 enhances p73 transcriptional activity and degrades ATR kinase in lamin misexpressed cells. Compared to the important functions of other HECT type ubiquitin ligase, there is less study concerning the function and regulation of NEDL2. Using primary antibody immunoprecipitation and mass spectrometry (IP/MS), we identify a list of potential ... [more]

J. Biol. Chem. Oct. 25, 2013; 0(0); [Pubmed: 24163370]

Throughput

  • High Throughput

Curated By

  • BioGRID