EID1
Gene Ontology Biological Process
Gene Ontology Molecular Function
PCID2
Gene Ontology Biological Process
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cysteine-type endopeptidase activity [ISO]
- positive regulation of B cell differentiation [IMP]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- regulation of mRNA stability [ISO]
- spleen development [IMP]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of Eid1 stability.
Self-renewal and differentiation are the hallmarks of embryonic stem cells (ESCs). However, it is largely unknown about how the pluripotency is regulated. Here we demonstrate that Pcid2 is required for the maintenance of self-renewal both in mouse and human ESCs. Pcid2 plays a critical role in suppression of ESC differentiation. Pcid2 deficiency causes early embryonic lethality before the blastocyst stage. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID