IL4RA
Gene Ontology Biological Process
- defense response to protozoan [IMP]
- immunoglobulin mediated immune response [IMP]
- negative regulation of T-helper 1 cell differentiation [IGI]
- positive regulation of T-helper 2 cell differentiation [IGI]
- positive regulation of chemokine secretion [IMP]
- positive regulation of immunoglobulin production [IMP]
- positive regulation of macrophage activation [IMP]
- positive regulation of mast cell degranulation [IMP]
- positive regulation of myoblast fusion [IMP]
- regulation of cell proliferation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of IL-4 Receptor Signaling by STUB1 in Lung Inflammation.
Rationale: Interleukin-4 receptor α (IL-4Rα), the common receptor component for IL-4 and IL-13, plays a critical role in IL-4 and IL-13-mediated signaling pathways that regulate airway inflammation and remodeling. However, the regulatory mechanisms underlying IL-4Rα turnover and its signal termination remain elusive. Objectives: To evaluate the role of STUB1 (STIP1 homology and U-Box containing protein 1) in regulating IL-4R signaling ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID