CDKN2A
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- Ras protein signal transduction [IEP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic mitochondrial changes [IMP]
- cell cycle arrest [IDA, IMP]
- cellular senescence [IMP]
- mitotic cell cycle [TAS]
- negative regulation of B cell proliferation [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of immature T cell proliferation in thymus [ISS]
- negative regulation of phosphorylation [IDA]
- negative regulation of protein kinase activity [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of ubiquitin-protein transferase activity [ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of protein sumoylation [IMP]
- positive regulation of smooth muscle cell apoptotic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein K63-linked ubiquitination [IDA]
- protein destabilization [IDA]
- protein polyubiquitination [IDA]
- protein stabilization [IDA]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of apoptotic DNA fragmentation [IMP]
- regulation of protein export from nucleus [IMP]
- regulation of protein stability [ISS]
- replicative senescence [IMP]
- senescence-associated heterochromatin focus assembly [IMP]
- somatic stem cell division [ISS]
Gene Ontology Molecular Function- MDM2/MDM4 family protein binding [IPI]
- NF-kappaB binding [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- ubiquitin-protein transferase inhibitor activity [ISS]
- MDM2/MDM4 family protein binding [IPI]
- NF-kappaB binding [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- ubiquitin-protein transferase inhibitor activity [ISS]
Gene Ontology Cellular Component
ACTB
Gene Ontology Biological Process
- 'de novo' posttranslational protein folding [TAS]
- ATP-dependent chromatin remodeling [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adherens junction organization [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component movement [TAS]
- cellular protein metabolic process [TAS]
- chromatin organization [TAS]
- innate immune response [TAS]
- membrane organization [TAS]
- platelet aggregation [IMP]
- protein folding [TAS]
- retina homeostasis [IEP]
- substantia nigra development [IEP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- Tat protein binding [IPI]
- kinesin binding [IPI]
- nitric-oxide synthase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- structural constituent of cytoskeleton [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- Tat protein binding [IPI]
- kinesin binding [IPI]
- nitric-oxide synthase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- structural constituent of cytoskeleton [TAS]
Gene Ontology Cellular Component
- MLL5-L complex [IDA]
- NuA4 histone acetyltransferase complex [IDA]
- blood microparticle [IDA]
- cytoplasm [TAS]
- cytoplasmic ribonucleoprotein granule [IDA]
- cytoskeleton [TAS]
- cytosol [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- nuclear chromatin [IDA]
- nucleoplasm [TAS]
- protein complex [IDA]
- ribonucleoprotein complex [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Proteomic analysis of p16ink4a-binding proteins.
The p16(ink4a) tumor suppressor protein plays a critical role in cell cycle control, tumorogenesis and senescence. The best known activity for p16(ink4a) is the inhibition of the activity of CDK4 and CDK6 kinases, both playing a key role in cell cycle progression. With the aim to study new p16(ink4a) functions we used affinity chromatography and MS techniques to identify new ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID