BAIT
BAG6
BAG-6, BAT3, D6S52E, G3, DADB-70P7.10-021
BCL2-associated athanogene 6
GO Process (14)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- brain development [ISS]
- embryo development [ISS]
- internal peptidyl-lysine acetylation [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- kidney development [ISS]
- lung development [ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- negative regulation of proteolysis [ISS]
- protein stabilization [ISS]
- spermatogenesis [ISS]
- synaptonemal complex assembly [ISS]
- tail-anchored membrane protein insertion into ER membrane [IDA]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRMT2
HRMT1L1
protein arginine methyltransferase 2
GO Process (12)
GO Function (14)
GO Component (5)
Gene Ontology Biological Process
- developmental cell growth [ISS]
- histone arginine methylation [IBA]
- histone methylation [IDA, ISS]
- negative regulation of G1/S transition of mitotic cell cycle [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of apoptotic process [IGI]
- positive regulation of transcription, DNA-templated [IDA]
- protein methylation [TAS]
- regulation of androgen receptor signaling pathway [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Y2H-seq approach defines the human protein methyltransferase interactome.
To accelerate high-density interactome mapping, we developed a yeast two-hybrid interaction screening approach involving short-read second-generation sequencing (Y2H-seq) with improved sensitivity and a quantitative scoring readout allowing rapid interaction validation. We applied Y2H-seq to investigate enzymes involved in protein methylation, a largely unexplored post-translational modification. The reported network of 523 interactions involving 22 methyltransferases or demethylases is comprehensively annotated and ... [more]
Nat. Methods Apr. 01, 2013; 10(4);339-42 [Pubmed: 23455924]
Throughput
- High Throughput
Additional Notes
- Hit identified by mass spec
Curated By
- BioGRID