NR1H3
Gene Ontology Biological Process
- apoptotic cell clearance [IMP]
- cellular response to lipopolysaccharide [IDA]
- cholesterol homeostasis [ISS]
- gene expression [TAS]
- intracellular receptor signaling pathway [TAS]
- lipid homeostasis [ISS]
- negative regulation of cholesterol storage [IMP]
- negative regulation of inflammatory response [ISS]
- negative regulation of interferon-gamma-mediated signaling pathway [NAS]
- negative regulation of lipid transport [IMP]
- negative regulation of macrophage activation [ISS]
- negative regulation of macrophage derived foam cell differentiation [IC]
- negative regulation of pancreatic juice secretion [ISS]
- negative regulation of pinocytosis [IMP]
- negative regulation of secretion of lysosomal enzymes [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol efflux [IDA, IMP]
- positive regulation of cholesterol homeostasis [IDA]
- positive regulation of cholesterol transport [IDA]
- positive regulation of fatty acid biosynthetic process [IMP]
- positive regulation of lipoprotein lipase activity [IMP]
- positive regulation of receptor biosynthetic process [IDA]
- positive regulation of toll-like receptor 4 signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of triglyceride biosynthetic process [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of circadian rhythm [TAS]
- response to progesterone [IDA]
- sterol homeostasis [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
- triglyceride homeostasis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SUV39H1
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- cellular response to hypoxia [IDA]
- chromatin organization [TAS]
- chromatin silencing at rDNA [IDA]
- histone H3-K9 dimethylation [ISS]
- histone H3-K9 trimethylation [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- chromatin binding [TAS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA]
- histone-lysine N-methyltransferase activity [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription regulatory region sequence-specific DNA binding [ISS]
- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- chromatin binding [TAS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA]
- histone-lysine N-methyltransferase activity [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Y2H-seq approach defines the human protein methyltransferase interactome.
To accelerate high-density interactome mapping, we developed a yeast two-hybrid interaction screening approach involving short-read second-generation sequencing (Y2H-seq) with improved sensitivity and a quantitative scoring readout allowing rapid interaction validation. We applied Y2H-seq to investigate enzymes involved in protein methylation, a largely unexplored post-translational modification. The reported network of 523 interactions involving 22 methyltransferases or demethylases is comprehensively annotated and ... [more]
Throughput
- High Throughput
Additional Notes
- Hit identified by mass spec
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR1H3 SUV39H1 | Affinity Capture-Luminescence Affinity Capture-Luminescence An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag. | High | - | BioGRID | - |
Curated By
- BioGRID