STK11
Gene Ontology Biological Process
- Golgi localization [IMP]
- T cell receptor signaling pathway [IGI, IMP]
- TCR signalosome assembly [IMP]
- activation of protein kinase activity [IDA, ISO]
- anoikis [ISO]
- axonogenesis [IMP, ISO]
- canonical Wnt signaling pathway [IMP]
- cell cycle arrest [ISO]
- dendrite extension [IMP]
- establishment of cell polarity [IMP]
- glucose homeostasis [IMP]
- intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of axonogenesis [IGI]
- positive regulation of gluconeogenesis [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP, ISO]
- positive thymic T cell selection [IMP]
- protein autophosphorylation [IDA, ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IMP, ISO]
- regulation of Wnt signaling pathway [IMP]
- regulation of cell growth [IDA]
- regulation of dendrite morphogenesis [IMP]
- regulation of protein kinase B signaling [IMP]
- response to ionizing radiation [IDA]
- response to lipid [ISO]
- spermatid development [IMP]
- tissue homeostasis [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.
LKB1 is a widely expressed serine/threonine protein kinase that is mutated in the inherited Peutz-Jeghers cancer syndrome. Recent findings indicate that LKB1 functions as a tumour suppressor, but little is known regarding the detailed mechanism by which LKB1 regulates cell growth. In this study we have purified LKB1 from cells and establish that it is associated with the heat-shock protein ... [more]
Throughput
- Low Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Additional Notes
- exogenous expression of bait
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STK11 HSP90AA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 919310 |
Curated By
- BioGRID