BAIT
CUT3
smc4, SPBC146.03c
condensin complex subunit Cut3
GO Process (3)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
TOP2
ptr11, SPBC1A4.03c
DNA topoisomerase II
GO Process (6)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- DNA strand elongation involved in mitotic DNA replication [ISO]
- DNA topological change [IDA, IGI, IMP]
- chromatin organization [IGI]
- mitotic chromosome condensation [IMP]
- resolution of meiotic recombination intermediates [IMP]
- transcription of nuclear large rRNA transcript from RNA polymerase I promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A Genetic Screen for Functional Partners of Condensin in Fission Yeast.
Mitotic chromosome condensation is a pre-requisite for the accurate segregation of chromosomes during cell division, and the conserved condensin complex a central player of this process. However, how condensin binds chromatin and shapes mitotic chromosomes remain poorly understood. Recent genome-wide binding studies showing that in most species condensin is enriched near highly expressed genes suggest a conserved link between condensin ... [more]
G3 (Bethesda) Dec. 20, 2013; 0(0); [Pubmed: 24362309]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- top2-250 and cut3-477 alleles
Curated By
- BioGRID