A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

A Genetic Screen for Functional Partners of Condensin in Fission Yeast.

Robellet X, Fauque L, Legros P, Mollereau E, Janczarski S, Parrinello H, Desvignes JP, Thevenin M, Bernard P

Mitotic chromosome condensation is a pre-requisite for the accurate segregation of chromosomes during cell division, and the conserved condensin complex a central player of this process. However, how condensin binds chromatin and shapes mitotic chromosomes remain poorly understood. Recent genome-wide binding studies showing that in most species condensin is enriched near highly expressed genes suggest a conserved link between condensin ... [more]

G3 (Bethesda) Dec. 20, 2013; 0(0); [Pubmed: 24362309]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

cut3-477 allele; 32 deg C.

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CUT3 CND1	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Sutani T (1999)	Low	-	BioGRID	-
CND1 CUT3	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Xu X (2015)	Low	-	BioGRID	2334459

Curated By

BioGRID

Interaction Summary

CUT3

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CND1