APBB1
Gene Ontology Biological Process
- axonogenesis [NAS]
- cell cycle arrest [ISS]
- cellular response to DNA damage stimulus [IDA]
- histone H4 acetylation [ISS]
- negative regulation of cell growth [ISS]
- negative regulation of thymidylate synthase biosynthetic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [ISS]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
THRAP3
Gene Ontology Biological Process
- androgen receptor signaling pathway [IDA]
- intracellular steroid hormone receptor signaling pathway [IDA]
- mRNA stabilization [IMP]
- nuclear-transcribed mRNA catabolic process [IDA]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of alternative mRNA splicing, via spliceosome [IMP]
- transcription initiation from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II transcription cofactor activity [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [NAS]
- phosphoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- receptor activity [IDA]
- thyroid hormone receptor binding [IDA]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IDA]
- vitamin D receptor binding [NAS]
- RNA polymerase II transcription cofactor activity [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [NAS]
- phosphoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- receptor activity [IDA]
- thyroid hormone receptor binding [IDA]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IDA]
- vitamin D receptor binding [NAS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
WW domains provide a platform for the assembly of multiprotein networks.
WW domains are protein modules that mediate protein-protein interactions through recognition of proline-rich peptide motifs and phosphorylated serine/threonine-proline sites. To pursue the functional properties of WW domains, we employed mass spectrometry to identify 148 proteins that associate with 10 human WW domains. Many of these proteins represent novel WW domain-binding partners and are components of multiprotein complexes involved in molecular ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID