BAIT

SCK2

SPAC22E12.14c
serine/threonine protein kinase Sck2
Schizosaccharomyces pombe (972h)
PREY

TRM10

SPAC6B12.09
tRNA m(1)G methyltransferase Trm10
GO Process (2)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C, Lopez-Maury L, Georgescu T, Pancaldi V, Baehler J

Target of rapamycin complex 1 (TORC1), which controls growth in response to nutrients, promotes ageing in multiple organisms. The fission yeast Schizosaccharomyces pombe emerges as a valuable genetic model system to study TORC1 function and cellular ageing. Here we exploited the combinatorial action of rapamycin and caffeine, which inhibit fission yeast growth in a TORC1-dependent manner. We screened a deletion ... [more]

Biol Open Jan. 24, 2014; 0(0); [Pubmed: 24463365]

Throughput

  • High Throughput

Curated By

  • BioGRID