BAIT
SCK2
SPAC22E12.14c
serine/threonine protein kinase Sck2
GO Process (4)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
SIR2
SPBC16D10.07c
Sir2 family histone deacetylase Sir2
GO Process (12)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- chromatin silencing [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- chromatin silencing at telomere [IMP]
- histone H3 deacetylation [IDA]
- histone H3-K9 modification [IDA]
- histone H4 deacetylation [IDA]
- histone deacetylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IEP]
- positive regulation of heterochromatin assembly [EXP]
- protein localization to chromosome, telomeric region [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase activity (H3-K14 specific) [IDA]
- histone deacetylase activity (H3-K4 specific) [IDA]
- histone deacetylase activity (H3-K9 specific) [IDA]
- histone deacetylase activity (H4-K16 specific) [IDA]
- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase activity (H3-K14 specific) [IDA]
- histone deacetylase activity (H3-K4 specific) [IDA]
- histone deacetylase activity (H3-K9 specific) [IDA]
- histone deacetylase activity (H4-K16 specific) [IDA]
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Target of rapamycin complex 1 (TORC1), which controls growth in response to nutrients, promotes ageing in multiple organisms. The fission yeast Schizosaccharomyces pombe emerges as a valuable genetic model system to study TORC1 function and cellular ageing. Here we exploited the combinatorial action of rapamycin and caffeine, which inhibit fission yeast growth in a TORC1-dependent manner. We screened a deletion ... [more]
Biol Open Jan. 24, 2014; 0(0); [Pubmed: 24463365]
Throughput
- High Throughput
Curated By
- BioGRID