ZSWIM7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
XRCC3
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IMP]
- DNA recombination [TAS]
- DNA repair [IGI]
- cellular response to DNA damage stimulus [TAS]
- double-strand break repair via homologous recombination [IMP]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
- regulation of centrosome duplication [IMP]
- resolution of mitotic recombination intermediates [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.
The Shu complex in yeast plays an important role in the homologous recombination pathway, which is critical for the maintenance of genomic integrity. The identification of human SWS1 (hSWS1) as the homolog of budding yeast Shu2 implicated that the Shu complex is evolutionarily conserved. However, the human counterparts of other components in this complex have not yet been identified and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID