CHRNA4
Gene Ontology Biological Process
- B cell activation [IMP]
- DNA repair [ISO]
- action potential [IMP]
- behavioral response to nicotine [IMP, ISO]
- calcium ion transport [IGI]
- cation transmembrane transport [IGI, ISO]
- cation transport [ISO]
- cognition [ISO]
- exploration behavior [IMP]
- ion transmembrane transport [IDA]
- locomotory behavior [IMP]
- membrane depolarization [IGI, IMP]
- neurological system process [IMP, ISO]
- positive regulation of dopamine secretion [ISO]
- protein heterooligomerization [ISO]
- regulation of dopamine secretion [IMP]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- regulation of membrane potential [IGI]
- respiratory gaseous exchange [IMP]
- response to hypoxia [ISO]
- response to nicotine [IGI, IMP, ISO]
- response to oxidative stress [ISO]
- sensory perception of pain [IMP, TAS]
- signal transduction [ISO]
- synaptic transmission, cholinergic [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LYNX1
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1.
We previously identified lynx1 as a neuronal membrane molecule related to snake alpha-neurotoxins able to modulate nAChRs. Here, we show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs. Single-channel recordings show that lynx1 promotes the largest of three current amplitudes elicited by ACh through alpha(4)beta(2) nAChRs and that lynx1 enhances desensitization. Macroscopic recordings quantify the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID