BAIT
SHANK2
AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3
SH3 and multiple ankyrin repeat domains 2
GO Process (7)
GO Function (3)
GO Component (14)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical plasma membrane [ISS]
- brush border membrane [ISS]
- ciliary membrane [ISS]
- dendritic spine [ISS]
- growth cone [ISS]
- ionotropic glutamate receptor complex [ISS]
- neurofilament [ISS]
- neuron projection [ISS]
- neuronal cell body [ISS]
- photoreceptor inner segment [ISS]
- photoreceptor outer segment [ISS]
- plasma membrane [ISS]
- postsynaptic density [ISS]
- postsynaptic membrane [ISS]
Homo sapiens
PREY
SHARPIN
SIPL1, PSEC0216
SHANK-associated RH domain interactor
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.
Shank/ProSAP proteins are major scaffold proteins of the postsynaptic density; mutations in the human SHANK3 gene are associated with intellectual disability or autism spectrum disorders. We have analyzed the functional relevance of several SHANK3 missense mutations affecting the N-terminal portion of the protein by expression of wild-type and mutant Shank3 in cultured neurons and by binding assays in heterologous cells. ... [more]
J. Biol. Chem. Sep. 13, 2013; 288(37);26697-708 [Pubmed: 23897824]
Throughput
- Low Throughput
Curated By
- BioGRID