BAIT
TSC2
SPAC630.13c
tuberin
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
GTR2
SPCC777.05
Gtr1/RagA G protein Gtr2 (predicted)
GO Process (1)
GO Function (0)
GO Component (3)
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.
TOR proteins reside in two distinct complexes, TOR complex 1 and 2 (TORC1 and TORC2) that are central for the regulation of cellular growth, proliferation and survival. TOR is also the target for the immunosuppressive and anti-cancer drug rapamycin. In Schizosaccharaomyces pombe, disruption of the TSC complex, mutations in which can lead to the Tuberous Sclerosis syndrome in humans, results ... [more]
Mol. Cell. Biol. Dec. 16, 2013; 0(0); [Pubmed: 24344203]
Throughput
- Low Throughput
Ontology Terms
- phenotype: utilization of nitrogen source (APO:0000099)
Additional Notes
- proline
Related interactions
Curated By
- BioGRID