A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.

Laor D, Cohen A, Pasmanik-Chor M, Oron-Karni V, Kupiec M, Weisman R

TOR proteins reside in two distinct complexes, TOR complex 1 and 2 (TORC1 and TORC2) that are central for the regulation of cellular growth, proliferation and survival. TOR is also the target for the immunosuppressive and anti-cancer drug rapamycin. In Schizosaccharaomyces pombe, disruption of the TSC complex, mutations in which can lead to the Tuberous Sclerosis syndrome in humans, results ... [more]

Mol. Cell. Biol. Dec. 16, 2013; 0(0); [Pubmed: 24344203]

Throughput

Low Throughput

Ontology Terms

phenotype: utilization of nitrogen source (APO:0000099)

Additional Notes

proline

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
TSC1 ISP7	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Laor D (2013)	Low	-	BioGRID	932929

Curated By

BioGRID

Interaction Summary

TSC1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

ISP7