RNH203
Gene Ontology Biological Process
Gene Ontology Molecular Function
RAD50
Gene Ontology Biological Process
- base-excision repair [IMP]
- double-strand break repair via break-induced replication [TAS]
- double-strand break repair via nonhomologous end joining [IMP]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA double-strand break processing [TAS]
- meiotic nuclear division [IMP]
- mitochondrial double-strand break repair via homologous recombination [IMP]
- negative regulation of endodeoxyribonuclease activity [IDA]
- telomere maintenance [IMP]
- telomere maintenance via recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
A Saccharomyces cerevisiae Ribonuclease H2 interaction network functions to suppress genome instability.
Errors during DNA replication are one likely cause of gross chromosomal rearrangements (GCRs). Here we analyze the role of RNase H2, which functions to process Okazaki fragments, degrade transcription intermediates and repair misincorporated ribonucleotides, in preventing genome instability. The results demonstrate that rnh203 mutations result in a weak mutator phenotype and cause growth defects and synergistic increases in GCR rates ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: cellular morphology (APO:0000050)
Additional Notes
- RNase H2 defect caused cell cycle delays in mutants that lead to different budding indexes for double mutant strains compared to single mutants
- strong synthetic growth defect was observed in double mutants
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD50 RNH203 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.155 | BioGRID | 408373 | |
| RAD50 RNH203 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1821 | BioGRID | 2173570 | |
| RAD50 RNH203 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 3395192 | |
| RAD50 RNH203 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 933036 |
Curated By
- BioGRID