RAD27
Gene Ontology Biological Process
- DNA replication, removal of RNA primer [IDA]
- base-excision repair, base-free sugar-phosphate removal [IGI, IMP]
- double-strand break repair via nonhomologous end joining [IDA]
- gene conversion at mating-type locus, DNA repair synthesis [IMP]
- maintenance of DNA trinucleotide repeats [IGI, IMP]
- replicative cell aging [IMP]
Gene Ontology Molecular Function
RNH203
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
A Saccharomyces cerevisiae Ribonuclease H2 interaction network functions to suppress genome instability.
Errors during DNA replication are one likely cause of gross chromosomal rearrangements (GCRs). Here we analyze the role of RNase H2, which functions to process Okazaki fragments, degrade transcription intermediates and repair misincorporated ribonucleotides, in preventing genome instability. The results demonstrate that rnh203 mutations result in a weak mutator phenotype and cause growth defects and synergistic increases in GCR rates ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- RNase H2 defect caused decrease in growth rate of mutants
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RAD27 RNH203 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1588 | BioGRID | 394116 | |
RAD27 RNH203 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1387 | BioGRID | 2143639 | |
RNH203 RAD27 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4328 | BioGRID | 2151321 | |
RNH203 RAD27 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 341581 | |
RAD27 RNH203 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 455850 | |
RAD27 RNH203 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 166736 |
Curated By
- BioGRID