BAIT
HACE1
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
GO Process (7)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CAPZB
1700120C01Rik, AI325129, CPB1, CPB2, CPbeat2, CPbeta1, CPbeta2, Cappb1, RP23-247I1.3
capping protein (actin filament) muscle Z-line, beta
GO Process (12)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- barbed-end actin filament capping [IDA]
- cell morphogenesis [IBA]
- cell projection organization [IMP]
- cytoskeleton organization [ISO]
- lamellipodium assembly [IMP]
- muscle fiber development [IMP]
- negative regulation of filopodium assembly [IBA]
- negative regulation of microtubule polymerization [IDA]
- neuron projection development [IMP]
- regulation of cell morphogenesis [ISO]
- regulation of lamellipodium assembly [IBA]
- regulation of protein kinase C signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.
The HECT E3 ubiquitin ligase HACE1 is a tumour suppressor known to regulate Rac1 activity under stress conditions. HACE1 is increased in the serum of patients with heart failure. Here we show that HACE1 protects the heart under pressure stress by controlling protein degradation. Hace1 deficiency in mice results in accelerated heart failure and increased mortality under haemodynamic stress. Hearts ... [more]
Nat Commun Mar. 13, 2014; 5(0);3430 [Pubmed: 24614889]
Throughput
- High Throughput
Curated By
- BioGRID