BAIT
HACE1
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
GO Process (7)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TPM1
AA986836, AI854628, TM2, Tm3, Tmpa, Tpm-1, alpha-TM
tropomyosin 1, alpha
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- actin filament capping [ISO]
- cardiac muscle contraction [IMP, ISO]
- embryo development [IMP]
- in utero embryonic development [IMP]
- muscle filament sliding [ISO]
- negative regulation of cell migration [ISO]
- positive regulation of ATPase activity [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of heart rate by epinephrine [IMP]
- positive regulation of stress fiber assembly [ISO]
- regulation of ATPase activity [ISO]
- ruffle organization [ISO]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.
The HECT E3 ubiquitin ligase HACE1 is a tumour suppressor known to regulate Rac1 activity under stress conditions. HACE1 is increased in the serum of patients with heart failure. Here we show that HACE1 protects the heart under pressure stress by controlling protein degradation. Hace1 deficiency in mice results in accelerated heart failure and increased mortality under haemodynamic stress. Hearts ... [more]
Nat Commun Mar. 13, 2014; 5(0);3430 [Pubmed: 24614889]
Throughput
- High Throughput
Curated By
- BioGRID