BAIT
CBS
HIP4
cystathionine-beta-synthase
GO Process (10)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- L-cysteine catabolic process [IDA]
- L-serine catabolic process [IDA]
- L-serine metabolic process [IDA]
- cellular nitrogen compound metabolic process [TAS]
- homocysteine catabolic process [IDA]
- homocysteine metabolic process [IDA]
- hydrogen sulfide biosynthetic process [IDA, ISS]
- small molecule metabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
- transsulfuration [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
RANBP9
BPM-L, BPM90, RANBPM, RanBP7
RAN binding protein 9
GO Process (3)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Human cystathionine beta-synthase is a target for sumoylation.
Cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits the toxic metabolite, homocysteine, to the synthesis of cysteine. Mutations in CBS are the most common cause of severe hereditary hyperhomocysteinemia. The molecular basis of the organ-specific pathologies associated with CBS deficiency is unknown as is the significance of the reported interaction between CBS and Huntingtin ... [more]
Biochemistry Nov. 14, 2006; 45(45);13528-36 [Pubmed: 17087506]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Curated By
- BioGRID