BAIT
WWOX
D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1
WW domain containing oxidoreductase
GO Process (7)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- cellular response to transforming growth factor beta stimulus [IDA]
- negative regulation of Wnt signaling pathway [IDA]
- oxidation-reduction process [TAS]
- positive regulation of extrinsic apoptotic signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- skeletal system morphogenesis [ISS]
- steroid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WASL
N-WASP, NWASP
Wiskott-Aldrich syndrome-like
GO Process (15)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- actin polymerization or depolymerization [TAS]
- axon guidance [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- membrane budding [ISS]
- negative regulation of membrane tubulation [IDA]
- nitric oxide metabolic process [TAS]
- positive regulation of clathrin-mediated endocytosis [ISS]
- positive regulation of filopodium assembly [ISS]
- protein complex assembly [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- small molecule metabolic process [TAS]
- vesicle organization [ISS]
- vesicle transport along actin filament [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Characterizing WW Domain Interactions of Tumor Suppressor WWOX Reveals its Association with Multiprotein Networks.
WW domains are small modules present in regulatory and signaling proteins that mediate specific protein-protein interactions. The WW domain-containing oxidoreductase (WWOX) encodes a 46-kDa tumor suppressor that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. Based on its ligand recognition motifs, the WW domain family is classified into four groups. The largest one, to which WWOX belongs, ... [more]
J. Biol. Chem. Feb. 18, 2014; 0(0); [Pubmed: 24550385]
Throughput
- High Throughput
Curated By
- BioGRID