CRK
Gene Ontology Biological Process
- activation of JUN kinase activity [TAS]
- ephrin receptor signaling pathway [ISO, ISS]
- positive regulation of signal transduction [ISO]
- regulation of Rac protein signal transduction [IMP]
- regulation of Rho GTPase activity [ISO, ISS]
- regulation of actin cytoskeleton organization [ISO, ISS]
- regulation of cellular component movement [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PXN
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- branching morphogenesis of an epithelial tube [ISO]
- cellular component movement [ISO]
- cellular response to reactive oxygen species [ISO]
- cytoskeleton organization [ISO]
- focal adhesion assembly [ISO]
- growth hormone receptor signaling pathway [ISO]
- integrin-mediated signaling pathway [ISO]
- lamellipodium assembly [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein kinase activity [ISO]
- regulation of cell shape [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors.
We examined the potential role of Crk-II in insulin and epidermal growth factor (EGF) signaling in Rat-1 fibroblasts overexpressing insulin receptors. Crk is an SH2 and SH3 domain-containing adaptor protein that has been reported to associate with p130cas, paxillin, c-cbl, c-abl, Sos, and C3G in vitro. Insulin- and EGF-induced association of Crk-II with these molecules was assessed by immunoblotting of ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CRK PXN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID