BAIT
ERG
erg-3, p55
v-ets avian erythroblastosis virus E26 oncogene homolog
GO Process (7)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SYN1
SYN1a, SYN1b, SYNI, RP1-230G1.2
synapsin I
GO Process (3)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.
The transcription factor E-twenty-six related gene (ERG), which is overexpressed through gene fusion with the androgen-responsive gene transmembrane protease, serine 2 (TMPRSS2) in ∼40% of prostate tumors, is a key driver of prostate carcinogenesis. Ablation of ERG would disrupt a key oncogenic transcriptional circuit and could be a promising therapeutic strategy for prostate cancer treatment. Here, we show that ubiquitin-specific ... [more]
Proc. Natl. Acad. Sci. U.S.A. Mar. 03, 2014; 0(0); [Pubmed: 24591637]
Throughput
- High Throughput
Additional Notes
- hits identified in both an in vitro GST-ERG pulldown and immunoprecipitation with an ERG antibody in a fusion TMPRSS2-ERG expressing cell
Related interactions
Curated By
- BioGRID