BAIT
HOMER3
AW146114
homer homolog 3 (Drosophila)
GO Process (2)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GRM1
4930455H15Rik, ENSMUSG00000075319, Gm10828, Gprc1a, mGluR1, nmf373, rcw, wobl
glutamate receptor, metabotropic 1
GO Process (15)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO]
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [IDA]
- activation of MAPKK activity [IDA]
- calcium-mediated signaling [ISO]
- cellular response to electrical stimulus [IMP]
- dimeric G-protein coupled receptor signaling pathway [ISO]
- locomotory behavior [IMP]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA]
- regulation of MAPK cascade [IDA]
- regulation of sensory perception of pain [IDA]
- regulation of synaptic transmission, glutamatergic [IBA, ISO]
- sensory perception of pain [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- G-protein coupled receptor dimeric complex [ISO]
- G-protein coupled receptor homodimeric complex [ISO]
- axon [ISO]
- cytosol [ISO]
- dendrite [IDA]
- dendritic spine [ISO]
- integral component of plasma membrane [IBA, ISO]
- intracellular [ISO]
- neuron projection [IDA]
- neuronal cell body [TAS]
- nucleus [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [TAS]
- presynaptic membrane [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Proteasomal degradation of the metabotropic glutamate receptor 1α is mediated by Homer-3 via the proteasomal S8 ATPase: Signal transduction and synaptic transmission.
J. Neurochem. (2012) 122, 24-37. ABSTRACT: The metabotropic glutamate receptors (mGluRs) fine-tune the efficacy of synaptic transmission. This unique feature makes mGluRs potential targets for the treatment of various CNS disorders. There is ample evidence to show that the ubiquitin proteasome system mediates changes in synaptic strength leading to multiple forms of synaptic plasticity. The present study describes a novel ... [more]
J. Neurochem. Jul. 01, 2012; 122(1);24-37 [Pubmed: 22486777]
Throughput
- Low Throughput
Curated By
- BioGRID