PIK3R1
Gene Ontology Biological Process
- B cell differentiation [IMP]
- NFAT protein import into nucleus [IMP]
- cellular glucose homeostasis [IDA]
- cellular response to UV [IGI, IMP]
- cellular response to insulin stimulus [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- glucose metabolic process [ISO]
- growth hormone receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of blood pressure [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cell-matrix adhesion [IGI]
- negative regulation of heart rate [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of osteoclast differentiation [IGI]
- negative regulation of proteolysis [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- phosphatidylinositol phosphorylation [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO, TAS]
- positive regulation of RNA splicing [ISO]
- positive regulation of cell migration [IGI, ISO]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of myoblast differentiation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription factor import into nucleus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of tumor necrosis factor production [IMP]
- protein phosphorylation [IDA]
- protein stabilization [ISO]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
- response to cAMP [ISO]
- response to endoplasmic reticulum stress [IDA, ISO]
- response to glucocorticoid [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [ISO, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [ISO]
- ATPase binding [ISO]
- ErbB-3 class receptor binding [ISO]
- calmodulin binding [ISO]
- estrogen receptor binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- 1-phosphatidylinositol-3-kinase activity [ISO, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [ISO]
- ATPase binding [ISO]
- ErbB-3 class receptor binding [ISO]
- calmodulin binding [ISO]
- estrogen receptor binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
JUP
Gene Ontology Biological Process
- bundle of His cell to Purkinje myocyte communication [ISO]
- cell adhesion [IDA]
- cell migration [ISO]
- cellular response to indole-3-methanol [ISO]
- desmosome assembly [IMP, ISO]
- detection of mechanical stimulus [ISO]
- establishment of protein localization to plasma membrane [ISO]
- positive regulation of protein import into nucleus [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein heterooligomerization [ISO]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of nucleic acid-templated transcription [IBA]
- single organismal cell-cell adhesion [IMP, ISO]
- skin development [IMP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- actin cytoskeleton [ISO]
- apicolateral plasma membrane [ISO]
- catenin complex [IBA, ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- cytosol [IDA]
- desmosome [IDA, IMP, ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [ISO]
- focal adhesion [ISO]
- gamma-catenin-TCF7L2 complex [ISO]
- intercalated disc [ISO]
- intermediate filament [IDA]
- lateral plasma membrane [ISO]
- membrane [IDA]
- nucleus [IBA, ISO]
- plasma membrane [ISO]
- protein-DNA complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation.
Activation of the PI3K-Akt-FoxO pathway induces cell growth, whereas its inhibition reduces cell survival and, in muscle, causes atrophy. Here, we report a novel mechanism that suppresses PI3K-Akt-FoxO signaling. Although skeletal muscle lacks desmosomes, it contains multiple desmosomal components, including plakoglobin. In normal muscle plakoglobin binds the insulin receptor and PI3K subunit p85 and promotes PI3K-Akt-FoxO signaling. During atrophy, however, ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
JUP PIK3R1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID