CEBPA
Gene Ontology Biological Process
- acute-phase response [IEP]
- brown fat cell differentiation [ISO]
- cell differentiation [IEP]
- cell maturation [ISO]
- cellular response to lithium ion [ISO]
- cellular response to organic cyclic compound [ISO]
- cholesterol metabolic process [ISO]
- embryonic placenta development [ISO]
- fat cell differentiation [ISO]
- inner ear development [ISO]
- liver development [IEP, ISO]
- lung development [ISO]
- macrophage differentiation [ISO]
- mitochondrion organization [ISO]
- myeloid cell differentiation [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA]
- organ regeneration [IEP]
- positive regulation of fat cell differentiation [IMP, ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell proliferation [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA, ISO, TAS]
- response to glucocorticoid [IEP]
- response to nutrient [IEP]
- response to vitamin B2 [IEP]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
- urea cycle [ISO]
- white fat cell differentiation [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA, IPI]
- protein homodimerization activity [IDA, IPI, ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA, IPI]
- protein homodimerization activity [IDA, IPI, ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
SUMO1
Gene Ontology Biological Process
- PML body organization [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- palate development [ISO, ISS]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein localization to nuclear pore [ISO]
- protein sumoylation [ISO, ISS]
- regulation of calcium ion transmembrane transport [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of protein stability [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes.
The expression changes of liver X receptor alpha (LXRα), histone deacetylase 3 (HDAC3) and CCAAT/enhancer binding protein alpha (C/EBPα) were detected in liver tissues of our high-fat-diet E3 rat model. The aim of this study is to pinpoint the molecular mechanism of HDAC3 and C/EBPα to orchestrate LXRα expression in hepatocytes. We confirmed that LXRα and its target genes were ... [more]
Throughput
- Low Throughput
Additional Notes
- likely sumo conjugate
Curated By
- BioGRID