OPTN
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- Golgi organization [IMP]
- Golgi ribbon formation [IDA]
- Golgi to plasma membrane protein transport [IMP]
- cell death [TAS]
- defense response to Gram-negative bacterium [IMP]
- macroautophagy [IDA]
- mitotic cell cycle [TAS]
- negative regulation of receptor recycling [IMP]
- protein targeting to Golgi [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IBA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB8A
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi vesicle fusion to target membrane [IBA, ISO]
- Rab protein signal transduction [IBA]
- axonogenesis [IMP]
- cellular response to insulin stimulus [IMP]
- cilium assembly [ISO, ISS]
- glucose homeostasis [IC]
- intracellular protein transport [IBA]
- positive regulation of glucose import [IC]
- protein localization to plasma membrane [IDA]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- regulation of long-term neuronal synaptic plasticity [IDA, IMP]
- regulation of protein localization [IMP]
- regulation of protein transport [IDA, IMP]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- centrosome [ISO]
- ciliary basal body [ISO]
- cilium [ISO, ISS]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic vesicle membrane [TAS]
- dendrite [IDA]
- endosome [IBA]
- extracellular vesicular exosome [ISO]
- neuronal cell body [IDA]
- nonmotile primary cilium [ISO]
- nucleolus [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- phagocytic vesicle [ISO, ISS]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- primary cilium [ISO]
- recycling endosome [ISO]
- recycling endosome membrane [ISO, ISS]
- secretory granule membrane [IBA]
- synaptic vesicle [IBA]
- trans-Golgi network transport vesicle [IBA, ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Effects of mutations and deletions in the human optineurin gene.
Optineurin is a gene associated with normal tension glaucoma (NTG) and amyotrophic lateral sclerosis (ALS). Foci formation and functional consequences including Golgi fragmentation, impairment of vesicle trafficking and apoptosis were observed previously upon overexpression and/or mutation of optineurin. In the current study, a total of 15 GFP tagged constructs that included NTG (E50K and 2 bp-AG insertion), ALS (exon 5 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID