BAIT

SLX4

YLR135W

Endonuclease involved in processing DNA; acts during recombination and repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress

GO Process (6)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

DNA replication [IMP]

DNA-dependent DNA replication [IGI]

cellular response to DNA damage stimulus [IGI]

double-strand break repair via break-induced replication [IGI]

double-strand break repair via single-strand annealing, removal of nonhomologous ends [IGI, IMP]

interstrand cross-link repair [IGI]

Gene Ontology Molecular Function

5'-flap endonuclease activity [IDA]

Gene Ontology Cellular Component

Slx1-Slx4 complex [IPI]

nucleus [IC, IDA, IMP]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

AIM32

YML050W

Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss

GO Process (0)

GO Function (0)

GO Component (0)

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

Conditional Genetic Interactions of RTT107, SLX4, and HRQ1 Reveal Dynamic Networks Upon DNA Damage in Saccharomyces cerevisiae.

Leung GP, Aristizabal MJ, Krogan NJ, Kobor MS

The DNA damage response (DDR) is a dynamic process that is crucial for protecting the cell from challenges to genome integrity. Although many genome-wide studies in Saccharomyces cerevisiae have identified genes that contribute to resistance to DNA damaging agents, more work is needed to elucidate the changes in genetic interaction networks in response to DNA lesions. Here we used conditional ... [more]

G3 (Bethesda) Apr. 02, 2014; 0(0); [Pubmed: 24700328]

Throughput

High Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)
phenotype: resistance to chemicals (APO:0000087)

Additional Notes

hydroxyurea

Curated By

BioGRID

Interaction Summary