BAIT
SKP2
4930500A04Rik, FBXL1, FWD1, p45
S-phase kinase-associated protein 2 (p45)
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- G2/M transition of mitotic cell cycle [IGI, IMP]
- positive regulation of intracellular estrogen receptor signaling pathway [IGI]
- positive regulation of protein polyubiquitination [IDA]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein polyubiquitination [IDA]
- regulation of apoptotic process [ISO]
- regulation of cell cycle [IPI]
- ubiquitin-dependent protein catabolic process [IDA, IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
HSP90AB1
D6S182, HSP84, HSP90B, HSPC2, HSPCB, RP1-302G2.1
heat shock protein 90kDa alpha (cytosolic), class B member 1
GO Process (9)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- regulation of interferon-gamma-mediated signaling pathway [IMP]
- regulation of type I interferon-mediated signaling pathway [IMP]
- response to unfolded protein [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.
The programmed formation of specific tissues from embryonic stem cells is a major goal of regenerative medicine. To identify points of intervention in cardiac tissue formation, we performed an siRNA screen in murine embryonic stem cells to identify ubiquitin system genes that repress cardiovascular tissue formation. Our screen uncovered an F-box protein, Fbxl16, as a repressor of one of the ... [more]
Mol. Cell Proteomics Mar. 01, 2014; 13(3);780-91 [Pubmed: 24390425]
Throughput
- Low Throughput
Additional Notes
- source of Skp2 not clear
Curated By
- BioGRID