BAIT
TRIM9
RNF91, SPRING
tripartite motif containing 9
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DCC
C030036D22Rik, Igdcc1
deleted in colorectal carcinoma
GO Process (10)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- anterior/posterior axon guidance [IMP]
- axon guidance [ISO]
- dorsal/ventral axon guidance [IMP]
- netrin-activated signaling pathway [ISO]
- neuron migration [IMP]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of neuron death [ISO]
- regulation of nucleic acid-templated transcription [ISO]
- spinal cord ventral commissure morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A novel Netrin-1-sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching.
Developmental axon branching dramatically increases synaptic capacity and neuronal surface area. Netrin-1 promotes branching and synaptogenesis, but the mechanism by which Netrin-1 stimulates plasma membrane expansion is unknown. We demonstrate that SNARE-mediated exocytosis is a prerequisite for axon branching and identify the E3 ubiquitin ligase TRIM9 as a critical catalytic link between Netrin-1 and exocytic SNARE machinery in murine cortical ... [more]
J. Cell Biol. Apr. 28, 2014; 205(2);217-32 [Pubmed: 24778312]
Throughput
- Low Throughput
Curated By
- BioGRID