BAIT
WNT3A
wingless-type MMTV integration site family, member 3A
GO Process (22)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- COP9 signalosome assembly [ISS]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [IDA]
- cell proliferation in forebrain [ISS]
- cellular response to retinoic acid [ISS]
- negative regulation of heart induction by canonical Wnt signaling pathway [IDA]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron projection development [ISS]
- neuron differentiation [IBA, ISS]
- palate development [IMP]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of dermatome development [IDA]
- positive regulation of mesodermal cell fate specification [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KCTD1
C18orf5, SENS, hCG_38480
potassium channel tetramerization domain containing 1
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
KCTD1 Suppresses Canonical Wnt Signaling Pathway by Enhancing β-catenin Degradation.
The canonical Wnt signaling pathway controls normal embryonic development, cellular proliferation and growth, and its aberrant activity results in human carcinogenesis. The core component in regulation of this pathway is β-catenin, but molecular regulation mechanisms of β-catenin stability are not completely known. Here, our recent studies have shown that KCTD1 strongly inhibits TCF/LEF reporter activity. Moreover, KCTD1 interacted with β-catenin ... [more]
PLoS ONE Apr. 17, 2014; 9(4);e94343 [Pubmed: 24736394]
Throughput
- Low Throughput
Additional Notes
- source of Wnt-3a not clear
Curated By
- BioGRID