BAIT
AGO2
EIF2C2, Q10
argonaute RISC catalytic component 2
GO Process (18)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Notch signaling pathway [TAS]
- RNA phosphodiester bond hydrolysis, endonucleolytic [EXP, IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- gene silencing by RNA [ISS]
- innate immune response [TAS]
- mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translation involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translational initiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]
- pre-miRNA processing [IDA]
- translation [NAS]
- translational initiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LIG4
LIG4S
ligase IV, DNA, ATP-dependent
GO Process (27)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- DNA ligation [IDA]
- DNA ligation involved in DNA recombination [ISS]
- DNA ligation involved in DNA repair [IDA, ISS]
- DNA repair [TAS]
- T cell differentiation in thymus [ISS]
- T cell receptor V(D)J recombination [ISS]
- V(D)J recombination [IDA]
- cell proliferation [ISS]
- central nervous system development [ISS]
- chromosome organization [ISS]
- double-strand break repair [IDA, ISS, TAS]
- double-strand break repair via nonhomologous end joining [IDA, IMP, TAS]
- establishment of integrated proviral latency [TAS]
- in utero embryonic development [ISS]
- isotype switching [ISS]
- lagging strand elongation [IBA]
- negative regulation of neuron apoptotic process [ISS]
- neuron apoptotic process [ISS]
- nucleotide-excision repair, DNA gap filling [IDA]
- positive regulation of fibroblast proliferation [ISS]
- positive regulation of neurogenesis [ISS]
- pro-B cell differentiation [ISS]
- response to X-ray [IMP]
- response to gamma radiation [ISS]
- single strand break repair [IDA]
- somatic stem cell maintenance [ISS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM65 regulates microRNA activity by ubiquitination of TNRC6.
MicroRNAs (miRNAs) are small evolutionarily conserved regulatory RNAs that modulate mRNA stability and translation in a wide range of cell types. MiRNAs are involved in a broad array of biological processes, including cellular proliferation, differentiation, and apoptosis. To identify previously unidentified regulators of miRNA, we initiated a systematic discovery-type proteomic analysis of the miRNA pathway interactome in human cells. Six ... [more]
Proc. Natl. Acad. Sci. U.S.A. May. 13, 2014; 111(19);6970-5 [Pubmed: 24778252]
Throughput
- High Throughput
Curated By
- BioGRID