GPR37
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PICK1
Gene Ontology Biological Process
- ATP catabolic process [ISO, ISS]
- cellular response to decreased oxygen levels [IMP]
- cellular response to glucose starvation [IMP]
- dendritic spine maintenance [IMP]
- dendritic spine organization [IDA]
- dopamine transport [NAS]
- glial cell development [IMP]
- long term synaptic depression [IDA]
- monoamine transport [ISO, ISS]
- negative regulation of Arp2/3 complex-mediated actin nucleation [IDA]
- negative regulation of cell death [IDA]
- negative regulation of gene expression [IMP]
- positive regulation of receptor internalization [IDA]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO, ISS]
- protein phosphorylation [IDA]
- protein targeting [ISO]
- receptor clustering [IMP, ISO, ISS]
Gene Ontology Molecular Function- ATPase activity [ISO, ISS]
- Arp2/3 complex binding [IDA]
- G-protein coupled glutamate receptor binding [TAS]
- G-protein coupled receptor binding [IPI, TAS]
- GTPase binding [TAS]
- actin filament binding [IDA]
- enzyme binding [ISO]
- ephrin receptor binding [TAS]
- identical protein binding [IDA]
- protein C-terminus binding [IPI, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase C binding [IDA, ISO, ISS]
- receptor binding [IPI, ISO, ISS]
- receptor tyrosine kinase binding [TAS]
- ATPase activity [ISO, ISS]
- Arp2/3 complex binding [IDA]
- G-protein coupled glutamate receptor binding [TAS]
- G-protein coupled receptor binding [IPI, TAS]
- GTPase binding [TAS]
- actin filament binding [IDA]
- enzyme binding [ISO]
- ephrin receptor binding [TAS]
- identical protein binding [IDA]
- protein C-terminus binding [IPI, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase C binding [IDA, ISO, ISS]
- receptor binding [IPI, ISO, ISS]
- receptor tyrosine kinase binding [TAS]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- cytoplasm [ISO, ISS]
- dendrite [IDA]
- mitochondrion [ISO]
- neuron projection [IDA]
- neuronal postsynaptic density [ISO]
- perinuclear region of cytoplasm [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- postsynaptic density [IDA]
- presynaptic membrane [ISO, ISS]
- protein complex [IDA]
- synapse [IDA, ISO, ISS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death.
The parkin-associated endothelial-like receptor (PAELR, GPR37) is an orphan G protein-coupled receptor that interacts with and is degraded by parkin-mediated ubiquitination. Mutations in parkin are thought to result in PAELR accumulation and increase neuronal cell death in Parkinson's disease. In this study, we find that the protein interacting with C-kinase (PICK1) interacts with PAELR. Specifically, the Postsynaptic density protein-95/Discs large/ZO-1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID