BAIT

RNG9

SPBP8B7.02, SPBP8B7.02
contractile ring myosin V regulator Rng9
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

MYP2

myo3, SPAC4A8.05c
myosin II heavy chain Myo3
GO Process (3)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis.

Wang N, Lo Presti L, Zhu YH, Kang M, Wu Z, Martin SG, Wu JQ

The myosin-V family of molecular motors is known to be under sophisticated regulation, but our knowledge of the roles and regulation of myosin-Vs in cytokinesis is limited. Here, we report that the myosin-V Myo51 affects contractile ring assembly and stability during fission yeast cytokinesis, and is regulated by two novel coiled-coil proteins, Rng8 and Rng9. Both rng8Δ and rng9Δ cells ... [more]

J. Cell Biol. May. 12, 2014; 205(3);357-75 [Pubmed: 24798735]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)
  • phenotype: cytokinesis (APO:0000071)

Additional Notes

  • cytokinesis defects

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MYP2 RNG9
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-2.5178BioGRID
760758

Curated By

  • BioGRID