Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb.

Wu L, Li L, Zhou B, Qin Z, Dou Y

Histone H2B ubiquitination plays an important role in transcription regulation. It has been shown that H2B ubiquitination is regulated by multiple upstream events associated with elongating RNA polymerase. Here we demonstrate that H2B K34 ubiquitylation by the MOF-MSL complex is part of the protein networks involved in early steps of transcription elongation. Knocking down MSL2 in the MOF-MSL complex affects ... [more]

Mol. Cell May. 14, 2014; 0(0); [Pubmed: 24837678]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RNF20 MSL2	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Wu L (2014)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

MSL2

Gene Ontology Biological Process

Gene Ontology Cellular Component

RNF20

Gene Ontology Biological Process

Gene Ontology Molecular Function

histone binding [IDA]p53 binding [IDA]protein binding [IPI]transcription coactivator activity [IDA]ubiquitin protein ligase binding [IPI]ubiquitin-protein transferase activity [IDA]