BAIT
IRF4
AI385587, IRF-4, LSIRF, Spip, RP23-213G18.1
interferon regulatory factor 4
GO Process (17)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- T-helper 17 cell lineage commitment [IMP]
- defense response to protozoan [IMP]
- histone H3 acetylation [IMP]
- histone H4 acetylation [IMP]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of toll-like receptor signaling pathway [IMP]
- peptidyl-lysine methylation [IDA]
- positive regulation of DNA binding [IMP]
- positive regulation of interleukin-10 biosynthetic process [ISO]
- positive regulation of interleukin-13 biosynthetic process [ISO]
- positive regulation of interleukin-2 biosynthetic process [ISO]
- positive regulation of interleukin-4 biosynthetic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein methylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
STAT3
1110034C02Rik, AW109958, Aprf, RP23-279L23.5
signal transducer and activator of transcription 3
GO Process (35)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- astrocyte differentiation [IMP]
- cell proliferation [IDA]
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [IMP]
- eye photoreceptor cell differentiation [IMP]
- glucose homeostasis [IMP]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glycolytic process [IMP]
- negative regulation of hydrogen peroxide biosynthetic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of neuron migration [IGI]
- phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein import into nucleus [ISO]
- radial glial cell differentiation [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of transcription, DNA-templated [ISO, NAS]
- response to cytokine [ISO]
- response to estradiol [ISO]
- sexual reproduction [IMP]
- stem cell maintenance [IMP]
- temperature homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.
Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and T cell homeostasis. We identified an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and IRF4, which are required for optimal Prdm1 expression. Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most ... [more]
Immunity Dec. 18, 2009; 31(6);941-52 [Pubmed: 20064451]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID