BAIT
TARDBP
ALS10, TDP-43, RP4-635E18.2
TAR DNA binding protein
GO Process (4)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
LSM6
YDR378C
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
GO Process (8)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA splicing [TAS]
- exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mRNA splicing, via spliceosome [IBA]
- maturation of SSU-rRNA [IBA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 ubiquitinylation.
TDP-43 characterizes insoluble protein aggregates in distinct subtypes of frontotemporal lobar degeneration (FTLD-TDP) and amyotrophic lateral sclerosis (ALS). TDP-43 mediates many RNA processing steps within distinct protein complexes. Here we identify novel TDP-43 protein interactors in a yeast 2-hybrid screen using an adult human brain cDNA library. We confirmed the TDP-43 interaction of seven hits by co-immunoprecipitation and assessed their ... [more]
J. Biol. Chem. May. 13, 2014; 0(0); [Pubmed: 24825905]
Throughput
- Low Throughput
Curated By
- BioGRID