PIAS1
Gene Ontology Biological Process
- JAK-STAT cascade [ISA]
- mitotic S phase [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of nucleic acid-templated transcription [ISA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein sumoylation [ISO]
- positive regulation of smooth muscle cell differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein sumoylation [IDA]
- protein-DNA complex assembly [ISO]
- regulation of cell proliferation [IMP]
Gene Ontology Molecular Function
NDN
Gene Ontology Biological Process
- axon extension [IMP]
- axonal fasciculation [IMP]
- axonogenesis [IMP]
- cellular calcium ion homeostasis [TAS]
- central nervous system development [IMP]
- genetic imprinting [IMP]
- glial cell migration [IMP]
- multicellular organismal homeostasis [IMP]
- neuron development [IMP]
- neuron migration [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- post-embryonic development [IMP]
- regulation of cell growth [TAS]
- regulation of transcription, DNA-templated [IGI]
- respiratory gaseous exchange [IMP]
- respiratory system process [IMP]
- sensory perception of pain [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Necdin Promotes Ubiquitin-Dependent Degradation of PIAS1 SUMO E3 Ligase.
Necdin, a pleiotropic protein that promotes differentiation and survival of mammalian neurons, is a member of MAGE (melanoma antigen) family proteins that share a highly conserved MAGE homology domain. Several MAGE proteins interact with ubiquitin E3 ligases and modulate their activities. However, it remains unknown whether MAGE family proteins interact with SUMO (small ubiquitin-like modifier) E3 ligases such as PIAS ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NDN PIAS1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID