USP14
Gene Ontology Biological Process
- negative regulation of ER-associated ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of endopeptidase activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IBA, ISO]
- proteolysis [ISO]
- regulation of chemotaxis [ISO]
- regulation of proteasomal protein catabolic process [IBA, ISO]
- synaptic transmission [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ERN1
Gene Ontology Biological Process
- HAC1-type intron splice site recognition and cleavage [ISO]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, ISO]
- RNA splicing [ISO]
- activation of signaling protein activity involved in unfolded protein response [ISO]
- cell cycle arrest [IDA]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- endoplasmic reticulum unfolded protein response [IDA]
- endothelial cell proliferation [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA]
- mRNA cleavage [ISO]
- mRNA splicing, via endonucleolytic cleavage and ligation [ISO]
- peptidyl-serine autophosphorylation [ISO]
- positive regulation of RNA splicing [ISO]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO]
- protein autophosphorylation [IDA]
- protein phosphorylation [ISO]
- protein trans-autophosphorylation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α
Huntington's disease (HD) is an autosomal inherited neurological disease caused by a CAG-repeat expansion in the first exon of huntingtin gene encoding for the huntingtin protein (Htt). In HD, there is an accumulation of intracellular aggregates of mutant Htt that negatively influence cellular functions. The aggregates contain ubiquitin, and part of the HD pathophysiology could result from an imbalance in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID