BAIT

VAPB

ALS8, VAMP-B, VAP-B, RP5-1018E9.1

VAMP (vesicle-associated membrane protein)-associated protein B and C

GO Process (16)

GO Function (7)

GO Component (5)

Gene Ontology Biological Process

COPII-coated vesicle budding [IMP]

ER to Golgi vesicle-mediated transport [IMP]

activation of signaling protein activity involved in unfolded protein response [IDA]

cellular calcium ion homeostasis [IMP]

endoplasmic reticulum organization [IMP]

endoplasmic reticulum unfolded protein response [IMP]

modulation by virus of host morphology or physiology [IDA]

negative regulation by host of viral genome replication [IDA]

negative regulation by host of viral release from host cell [IDA]

negative regulation by virus of viral protein levels in host cell [IDA]

positive regulation by host of viral genome replication [IDA]

positive regulation by host of viral release from host cell [IDA]

positive regulation of viral genome replication [IMP]

small molecule metabolic process [TAS]

sphingolipid biosynthetic process [TAS]

sphingolipid metabolic process [TAS]

Gene Ontology Molecular Function

FFAT motif binding [IMP]
beta-tubulin binding [IDA]
enzyme binding [IPI]
microtubule binding [IDA]
protein binding [IPI]
protein heterodimerization activity [IPI]
protein homodimerization activity [IPI]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

Golgi membrane [IMP]

endoplasmic reticulum [IDA]

endoplasmic reticulum exit site [IDA]

endoplasmic reticulum membrane [IDA, TAS]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

GET4

C7orf20, CEE, TRC35, CGI-20

golgi to ER traffic protein 4 homolog (S. cerevisiae)

GO Process (1)

GO Function (0)

GO Component (2)

Gene Ontology Biological Process

tail-anchored membrane protein insertion into ER membrane [IMP]

Gene Ontology Cellular Component

BAT3 complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.

Baron Y, Pedrioli PG, Tyagi K, Johnson C, Wood NT, Fountaine D, Wightman M, Alexandru G

FAF1 is a ubiquitin-binding adaptor for the p97 ATPase and belongs to the UBA-UBX family of p97 cofactors. p97 converts the energy derived from ATP hydrolysis into conformational changes of the p97 hexamer, which allows the dissociation of its targets from cellular structures or from larger protein complexes to facilitate their ubiquitin-dependent degradation. VAPB and the related protein VAPA form ... [more]

BMC Biol. Jun. 03, 2014; 12(1);39 [Pubmed: 24885147]

Throughput

High Throughput

Curated By

BioGRID