BAIT
HMBS
PBGD, T25658, Ups, Uros1
hydroxymethylbilane synthase
GO Process (1)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
RANBP9
IBAP-1, Ibap1, RanBPM
RAN binding protein 9
GO Process (0)
GO Function (3)
GO Component (3)
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A porphobilinogen deaminase (PBGD) Ran-binding protein interaction is implicated in nuclear trafficking of PBGD in differentiating glioma cells.
Porphobilinogen deaminase (PBGD) is a rate-limiting enzyme of the heme biosynthesis pathway, whose level is elevated in various human tumors. PBGD was observed in both nuclear and cytoplasmic fractions of C6 glioma cells by immunostaining. During mitosis, chromatids were intensely stained for PBGD in comparison to the interphase chromatin. Using the yeast two-hybrid system, we identified RanBPM, the nuclear Ran-binding ... [more]
Oncogene Aug. 14, 2003; 22(34);5221-8 [Pubmed: 12917623]
Throughput
- Low Throughput
Curated By
- BioGRID