PTPRO
Gene Ontology Biological Process
- axon guidance [ISS]
- cell morphogenesis [ISS]
- glomerular visceral epithelial cell differentiation [ISS]
- glomerulus development [IMP]
- lamellipodium assembly [ISS]
- monocyte chemotaxis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of cell-substrate adhesion [ISS]
- negative regulation of glomerular filtration [ISS]
- negative regulation of neuron projection development [ISS]
- negative regulation of retinal ganglion cell axon guidance [ISS]
- peptidyl-tyrosine dephosphorylation [IMP]
- protein dephosphorylation [ISS, TAS]
- regulation of glomerular filtration [ISS]
- slit diaphragm assembly [ISS, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VIL1
Gene Ontology Biological Process
- actin filament capping [IDA]
- actin filament depolymerization [IDA]
- actin filament polymerization [IDA]
- actin filament severing [IDA]
- cellular response to epidermal growth factor stimulus [IDA]
- cytoplasmic actin-based contraction involved in cell motility [IDA]
- epidermal growth factor receptor signaling pathway [IDA]
- epithelial cell differentiation [IEP]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of epithelial cell migration [IDA]
- protein complex assembly [TAS]
- regulation of actin nucleation [IDA]
- regulation of cell shape [IDA]
- regulation of lamellipodium morphogenesis [ISS]
- regulation of wound healing [ISS]
- response to bacterium [IDA]
Gene Ontology Molecular Function- actin filament binding [IDA]
- calcium ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- identical protein binding [IPI]
- lysophosphatidic acid binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- actin filament binding [IDA]
- calcium ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- identical protein binding [IPI]
- lysophosphatidic acid binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.
We have previously reported that the gene encoding protein tyrosine phosphatase receptor type-O (PTPRO) is suppressed by promoter methylation in a rat model of hepatocellular carcinoma (HCC) and it functions as tumor suppressor in leukemia and lung cancer. Here, we explored the methylation and expression of PTPRO as well as its function in human HCC. MassARRAY analysis of primary human ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PTPRO VIL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID