RANBP9
Gene Ontology Biological Process
Gene Ontology Molecular Function
THRA
Gene Ontology Biological Process
- gene expression [TAS]
- hormone-mediated signaling pathway [IDA]
- negative regulation of DNA-templated transcription, initiation [IDA]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- TBP-class protein binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone binding [IDA, IPI]
- thyroid hormone receptor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- TBP-class protein binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone binding [IDA, IPI]
- thyroid hormone receptor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification and characterization of RanBPM, a novel coactivator of thyroid hormone receptors.
Thyroid hormone receptors (TRs) are transcription factor members of the nuclear receptor superfamily. The transcriptional activity of TRs is controlled by thyroid hormones and cell-specific coregulators. Using the yeast two-hybrid system, we identified RanBPM as a new protein partner for TRs. RanBPM was initially discovered as an interacting partner for Ran, and was also shown to be a protein partner ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID