APOC2
Gene Ontology Biological Process
- cholesterol efflux [IDA]
- cholesterol homeostasis [IC]
- chylomicron remnant clearance [IDA]
- chylomicron remodeling [IC]
- high-density lipoprotein particle clearance [IMP]
- lipoprotein metabolic process [TAS]
- negative regulation of catalytic activity [IDA]
- negative regulation of cholesterol transport [IMP]
- negative regulation of lipid metabolic process [IDA]
- negative regulation of receptor-mediated endocytosis [IDA]
- negative regulation of very-low-density lipoprotein particle clearance [IDA]
- phospholipid efflux [IDA]
- phototransduction, visible light [TAS]
- positive regulation of fatty acid biosynthetic process [IDA]
- positive regulation of lipoprotein lipase activity [IDA]
- positive regulation of phospholipase activity [IDA]
- positive regulation of phospholipid catabolic process [IDA]
- positive regulation of triglyceride catabolic process [IDA]
- positive regulation of very-low-density lipoprotein particle remodeling [IC]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IC]
- small molecule metabolic process [TAS]
- triglyceride homeostasis [IMP]
- triglyceride-rich lipoprotein particle remodeling [TAS]
- very-low-density lipoprotein particle remodeling [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- chylomicron [IDA]
- early endosome [TAS]
- extracellular region [NAS, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- intermediate-density lipoprotein particle [IDA]
- low-density lipoprotein particle [IDA]
- spherical high-density lipoprotein particle [IDA]
- very-low-density lipoprotein particle [IDA]
CRYAB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Avoiding the oligomeric state: αB-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils.
The in vivo aggregation of proteins into amyloid fibrils suggests that cellular mechanisms that normally prevent or reverse this aggregation have failed. The small heat-shock molecular chaperone protein αB-crystallin (αB-c) inhibits amyloid formation and colocalizes with amyloid plaques; however, the physiological reason for this localization remains unexplored. Here, using apolipoprotein C-II (apoC-II) as a model fibril-forming system, we show that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID