BAIT

XIRP1

CMYA1, Xin
xin actin-binding repeat containing 1
GO Process (0)
GO Function (2)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens
PREY

ENAH

ENA, MENA, NDPP1, RP11-496N12.7
enabled homolog (Drosophila)
GO Process (2)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.

van der Ven PF, Ehler E, Vakeel P, Eulitz S, Schenk JA, Milting H, Micheel B, Fuerst DO

Filamin c is the predominantly expressed filamin isoform in striated muscles. It is localized in myofibrillar Z-discs, where it binds FATZ and myotilin, and in myotendinous junctions and intercalated discs. Here, we identify Xin, the protein encoded by the human gene 'cardiomyopathy associated 1' (CMYA1) as filamin c binding partner at these specialized structures where the ends of myofibrils are ... [more]

Exp. Cell Res. Jul. 01, 2006; 312(11);2154-67 [Pubmed: 16631741]

Throughput

  • Low Throughput

Additional Notes

  • Figure 4

Curated By

  • BioGRID