BAIT
XIRP1
CMYA1, Xin
xin actin-binding repeat containing 1
GO Process (0)
GO Function (2)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
EVL
RNB6
Enah/Vasp-like
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- actin filament organization [TAS]
- actin polymerization or depolymerization [ISS]
- axon guidance [TAS]
- cell surface receptor signaling pathway [NAS]
- negative regulation of epithelial cell migration [IMP]
- negative regulation of ruffle assembly [IMP]
- nervous system development [NAS]
- organ morphogenesis [NAS]
- positive regulation of stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.
Filamin c is the predominantly expressed filamin isoform in striated muscles. It is localized in myofibrillar Z-discs, where it binds FATZ and myotilin, and in myotendinous junctions and intercalated discs. Here, we identify Xin, the protein encoded by the human gene 'cardiomyopathy associated 1' (CMYA1) as filamin c binding partner at these specialized structures where the ends of myofibrils are ... [more]
Exp. Cell Res. Jul. 01, 2006; 312(11);2154-67 [Pubmed: 16631741]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Curated By
- BioGRID