BAIT
PRKCB
Pkcb, Prkcb1
protein kinase C, beta
GO Process (25)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- B cell activation [ISO, ISS]
- B cell receptor signaling pathway [ISO, ISS]
- calcium ion transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to carbohydrate stimulus [ISO]
- dibenzo-p-dioxin metabolic process [IEP]
- histone H3-T6 phosphorylation [ISO, ISS]
- intracellular signal transduction [NAS]
- negative regulation of glucose transport [ISO, ISS]
- negative regulation of insulin receptor signaling pathway [IDA]
- positive regulation of B cell receptor signaling pathway [ISO, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of angiogenesis [ISO, ISS]
- positive regulation of odontogenesis of dentin-containing tooth [IEP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of dopamine secretion [IMP]
- regulation of growth [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- response to drug [IMP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to hypoxia [ISO]
- response to vitamin D [IEP]
Gene Ontology Molecular Function- androgen receptor binding [ISO, ISS]
- calcium channel regulator activity [ISO]
- chromatin binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-T6 specific) [ISO, ISS]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO, ISS]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [ISO]
- androgen receptor binding [ISO, ISS]
- calcium channel regulator activity [ISO]
- chromatin binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-T6 specific) [ISO, ISS]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO, ISS]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
BCL2
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
B cell leukemia/lymphoma 2
GO Process (135)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- B cell homeostasis [IMP]
- B cell lineage commitment [IMP]
- B cell proliferation [ISO]
- B cell receptor signaling pathway [ISO]
- CD8-positive, alpha-beta T cell lineage commitment [IMP]
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- T cell homeostasis [IGI, IMP]
- T cell lineage commitment [IMP]
- actin filament organization [IMP]
- apoptotic mitochondrial changes [IDA]
- apoptotic process [IMP, ISO]
- axon regeneration [IDA]
- axonogenesis [IMP]
- behavioral fear response [IMP]
- branching involved in ureteric bud morphogenesis [IDA, IGI]
- cell aging [IMP]
- cell growth [IMP]
- cell morphogenesis [IMP]
- cell proliferation [IGI]
- cellular calcium ion homeostasis [IDA]
- cellular response to DNA damage stimulus [ISO]
- cellular response to glucose starvation [IDA]
- cellular response to hypoxia [IDA]
- cellular response to organic substance [IDA]
- cochlear nucleus development [IMP]
- defense response to virus [ISO]
- developmental growth [IMP]
- developmental pigmentation [IGI, IMP]
- digestive tract morphogenesis [IMP]
- ear development [IGI, IMP]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- focal adhesion assembly [IMP]
- gland morphogenesis [IMP]
- glomerulus development [IMP]
- growth [IMP]
- hair follicle morphogenesis [IMP]
- hemopoiesis [IMP]
- homeostasis of number of cells within a tissue [IMP]
- immune system development [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- kidney development [IGI, IMP]
- leukocyte homeostasis [IMP]
- lymphocyte homeostasis [IGI, IMP]
- lymphoid progenitor cell differentiation [IMP]
- male gonad development [IGI]
- melanin metabolic process [IMP]
- melanocyte differentiation [IGI, IMP]
- mesenchymal cell development [IMP]
- metanephros development [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA, IMP]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, IGI, IMP, ISO, ISS]
- negative regulation of apoptotic signaling pathway [IDA, ISO]
- negative regulation of calcium ion transport into cytosol [IGI]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of cellular pH reduction [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of neuron apoptotic process [IDA, IMP, ISO]
- negative regulation of ossification [IMP]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of retinal cell programmed cell death [IMP]
- neuron apoptotic process [IGI, IMP]
- oocyte development [IMP]
- organ growth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- ovarian follicle development [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pigment granule organization [IMP]
- pigmentation [IMP]
- positive regulation of B cell proliferation [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of developmental pigmentation [IGI, IMP]
- positive regulation of melanocyte differentiation [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of neuron maturation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of skeletal muscle fiber development [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- post-embryonic development [IGI, IMP]
- protein dephosphorylation [IDA]
- protein polyubiquitination [ISO]
- reactive oxygen species metabolic process [IMP]
- regulation of apoptotic process [IGI]
- regulation of calcium ion transport [ISO]
- regulation of catalytic activity [IMP]
- regulation of cell cycle [IMP]
- regulation of cell-matrix adhesion [IMP]
- regulation of developmental pigmentation [IGI]
- regulation of gene expression [IMP]
- regulation of glycoprotein biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IDA]
- regulation of mitochondrial membrane potential [IDA]
- regulation of nitrogen utilization [IGI]
- regulation of programmed cell death [IGI]
- regulation of protein heterodimerization activity [ISO]
- regulation of protein homodimerization activity [ISO]
- regulation of protein localization [IMP]
- regulation of protein stability [IMP]
- regulation of transmembrane transporter activity [ISO]
- regulation of viral genome replication [IDA]
- release of cytochrome c from mitochondria [IDA]
- renal system process [IMP]
- response to UV-B [IMP]
- response to acid chemical [IDA]
- response to cytokine [IMP, ISO]
- response to drug [IDA, ISO]
- response to gamma radiation [IMP]
- response to glucocorticoid [IDA, IMP]
- response to hydrogen peroxide [IMP]
- response to iron ion [ISO]
- response to ischemia [IMP]
- response to nicotine [ISO]
- response to oxidative stress [IMP]
- response to steroid hormone [IMP]
- response to toxic substance [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- spleen development [IGI, IMP]
- thymus development [IGI, IMP]
- transmembrane transport [ISO]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- endoplasmic reticulum [IDA, IGI, ISO]
- endoplasmic reticulum membrane [IDA]
- intracellular [IDA, IMP]
- membrane [IDA, ISO]
- mitochondrial membrane [IDA]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nuclear membrane [IDA, ISO]
- nucleus [IDA, ISO]
- pore complex [ISO]
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.
Using murine myeloid factor-dependent FDC-P1/ER cells, we demonstrate that the hematopoietic growth factors interleukin-3 and erythropoietin and bryostatin-1, a macrocyclic lactone natural product and potent activator of protein kinase C (PKC), suppress apoptosis and induce the rapid serine phosphorylation of Bc12 alpha. Expression of recombinant wild type Bc12 alpha in NFS/N1.H-7 cells confirms that murine Bc12 alpha is phosphorylated following ... [more]
J. Biol. Chem. Oct. 28, 1994; 269(43);26865-70 [Pubmed: 7929424]
Throughput
- Low Throughput
Curated By
- BioGRID