BAIT
NSD1
ARA267, KMT3B, SOTOS, SOTOS1, STO
nuclear receptor binding SET domain protein 1
GO Process (5)
GO Function (11)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- androgen receptor binding [IDA]
- chromatin binding [ISS]
- estrogen receptor binding [ISS]
- histone methyltransferase activity (H3-K36 specific) [IDA, ISS]
- histone methyltransferase activity (H4-K20 specific) [ISS]
- retinoic acid receptor binding [ISS]
- retinoid X receptor binding [ISS]
- thyroid hormone receptor binding [ISS]
- transcription cofactor activity [IDA]
- transcription corepressor activity [ISS]
- zinc ion binding [IDA]
- androgen receptor binding [IDA]
- chromatin binding [ISS]
- estrogen receptor binding [ISS]
- histone methyltransferase activity (H3-K36 specific) [IDA, ISS]
- histone methyltransferase activity (H4-K20 specific) [ISS]
- retinoic acid receptor binding [ISS]
- retinoid X receptor binding [ISS]
- thyroid hormone receptor binding [ISS]
- transcription cofactor activity [IDA]
- transcription corepressor activity [ISS]
- zinc ion binding [IDA]
Homo sapiens
PREY
NR2E1
TLL, TLX, XTLL, RP3-429G5.1
nuclear receptor subfamily 2, group E, member 1
GO Process (3)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.
Despite their physiological importance, selective interactions between nuclear receptors (NRs) and their cofactors are poorly understood. Here, we describe a novel signature motif (F/YSXXLXXL/Y) in the developmental regulator BCL11A that facilitates its selective interaction with members of the NR2E/F subfamily. Two copies of this motif (named here as RID1 and RID2) permit BCL11A to bind COUP-TFs (NR2F1;NR2F2;NR2F6) and Tailless/TLX (NR2E1), ... [more]
Nucleic Acids Res. Nov. 01, 2013; 41(21);9663-79 [Pubmed: 23975195]
Throughput
- Low Throughput
Additional Notes
- source of proteins unclear
Curated By
- BioGRID